Title of article
Pharmacophore identification of KSP inhibitors
Author/Authors
Fei Liu، نويسنده , , Qi-Dong You، نويسنده , , Yadong Chen ، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
722
To page
726
Abstract
A three-dimensional pharmacophore model was developed based on 25 currently available KSP (kinesin spindle protein) inhibitors in Catalyst software package. The best pharmacophore hypothesis (Hypo1), consisting of four chemical features (one hydrogen-bond acceptor, one hydrogen-bond donor, one aromatic ring, and one hydrophobic group), has a correlation coefficient of 0.965. The results of our study provide a valuable tool in designing new leads with desired biological activity by virtual screening.
Keywords
pharmacophore , Mitotic kinesin , KSP inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797727
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