Title of article
Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite
Author/Authors
Rena Nishizawa، نويسنده , , Toshihiko Nishiyama، نويسنده , , Katsuya Hisaichi، نويسنده , , Naoki Matsunaga، نويسنده , , Chiaki Minamoto، نويسنده , , Hiromu Habashita، نويسنده , , Yoshikazu Takaoka، نويسنده , , Masaaki Toda، نويسنده , , Shiro Shibayama، نويسنده , , Hideaki Tada، نويسنده , , Kenji Sagawa، نويسنده , , Daikichi Fukushima، نويسنده , , Kenji Maeda، نويسنده , , Hiroaki Mitsuya، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
727
To page
731
Abstract
Hydroxylated derivatives were designed and synthesized based on the information of oxidative metabolites. Compounds derived from β-substituted (2R,3R)-2-amino-3-hydroxypropionic acid showed improved inhibitory activities against the binding of MIP-1α to human CCR5, compared with the non-hydroxylated derivatives and the other isomers.
Keywords
CCR5 , HIV-1 , Active metabolite
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797728
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