Title of article :
Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers
Author/Authors :
Ahmed Kamal، نويسنده , , D. Rajasekhar Reddy، نويسنده , , P.S. Murali Mohan Reddy، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
C2R-Fluoro substituted DC-81 and its dimers have been synthesized that exhibit significant DNA-binding ability, particularly the five carbon alkane spacer compound (6c) showed the helix melting temperature (ΔTm) of 18.8 °C after incubation of 36 h at 37 °C.
Keywords :
DNA-binding ability , Pyrrolobenzodiazepine , DC-81
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
