Title of article
Diaryl substituted pyrazoles as potent CCR2 receptor antagonists
Author/Authors
Anthony B. Pinkerton، نويسنده , , Dehua Huang، نويسنده , , Rowena V. Cube، نويسنده , , John H. Hutchinson، نويسنده , , Mary Struthers، نويسنده , , Julia M. Ayala، نويسنده , , Pasquale P. Vicario، نويسنده , , Sima R. Patel، نويسنده , , Thomas Wisniewski، نويسنده , , Julie A. DeMartino، نويسنده , , Jean-Michel Vernier، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
807
To page
813
Abstract
We have identified and synthesized a series of diaryl substituted pyrazoles as potent antagonists of the chemokine receptor subtype 2. Structure–activity relationship studies directed toward improving the potency led to the discovery of 23 (IC50 = 6 nM).
Keywords
chemokines , GPCR , CCR2 , MCP-1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797745
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