Title of article
Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists—Increasing selectivity over hERG
Author/Authors
Kenneth M. Meyers، نويسنده , , Nicholas Kim، نويسنده , , Jose L. Mendez-Andino، نويسنده , , X. Eric Hu، نويسنده , , Rashid N. Mumin، نويسنده , , Sean R. Klopfenstein، نويسنده , , John A. Wos، نويسنده , , Maria C. Mitchell، نويسنده , , Jennifer L. Paris، نويسنده , , David C. Ackley، نويسنده , , Jerry K. Holbert، نويسنده , , Scott W. Mittelstadt، نويسنده , , Ofer Reizes، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
814
To page
818
Abstract
Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists with greater selectivity over hERG were identified. SAR studies addressing two distinct alternatives for structural modifications leading to improve hERG selectivity are described.
Keywords
Melanin-concentrating hormone , MCH-R1 antagonists , obesity , HERG , Aminomethyl tetrahydronaphthalene biphenyl carboxamide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797746
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