Title of article :
Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase
Author/Authors :
Yili Ding، نويسنده , , Kenneth L. Smith، نويسنده , , Chamakura V.N.S. Varaprasad، نويسنده , , Eugene Chang، نويسنده , , John Alexander، نويسنده , , Nanhua Yao، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Several thiazolone-based sulfonamides were prepared, utilizing various hetero-aryl sulfonyl chlorides and different aldehydes, as inhibitors of NS5B polymerase, to target HCV. The best compound showed 0.6 nM of IC50 inhibitory activity.
Keywords :
HCV , NS5B ploymerase inhibitor , synthesis
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
