Title of article
1,5-Benzodioxepin derivatives as a novel class of muscarinic M3 receptor antagonists
Author/Authors
Shuji Sonda، نويسنده , , Kenichi Katayama، نويسنده , , Masakazu Fujio، نويسنده , , Hiroshi Sakashita، نويسنده , , Kenichi Inaba، نويسنده , , Kiyoshi Asano، نويسنده , , Toshiaki Akira، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
925
To page
931
Abstract
The structure–activity relationships of novel 1,5-benzodioxepin derivatives as muscarinic M1–M3 receptor antagonists are reported. Some of these compounds were found to possess high binding affinity for the muscarinic M3 receptor and potent effect on rhythmic increase in bladder pressure in unanesthetized rats following oral administration. These compounds displayed selectivity for the bladder over the salivary gland.
Keywords
Urinary incontinence , 1 , Antagonists , 5-benzodioxepin derivatives , Muscarinic M1–M3 receptor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797765
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