Title of article
5-Propynylamino α-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic α-oligonucleotides
Author/Authors
Gaëlle Deglane، نويسنده , , François Morvan، نويسنده , , Françoise Debart، نويسنده , , Jean-Jacques Vasseur، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
951
To page
954
Abstract
Incorporation of 5-propynylamino and 5-propynyl α-2′-deoxyuridine into α-oligonucleotides (α-ON) allows high-affinity targeting of complementary DNA for α-ON with anionic and neutral backbone but not for cationic α-ON, revealing clues on the role of the amino group of the propynylamino on the formation of DNA duplexes.
Keywords
oligonucleotides , ?-Anomery , Phosphoramidates , Hybridization , Bas modification
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797770
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