Author/Authors :
Peter J. Lovell، نويسنده , , Frank E. Blaney، نويسنده , , Caroline J. Goodacre، نويسنده , , Claire M. Scott، نويسنده , , Paul W. Smith، نويسنده , , Kathryn R. Starr، نويسنده , , Kevin M. Thewlis، نويسنده , , Antonio K.K. Vong، نويسنده , , Simon E. Ward، نويسنده , , Jeannette M. Watson، نويسنده ,
Abstract :
Investigation of halogen substitution in lead compound 1 has led to the identification of analogues which combine high affinity for 5-HT1A receptors and potent serotonin reuptake inhibitory activity. Several compounds show an improved selectivity over 5-HT1B and 5-HT1D receptors and a superior pharmacokinetic profile in the rat.
