Author/Authors :
Changming Sun، نويسنده , , Lee-Gin Lin، نويسنده , , Hsi-Jung Yu، نويسنده , , Chih-Yu Cheng، نويسنده , , Ya-Chuan Tsai، نويسنده , , Chi-Wei Chu، نويسنده , , Yi-Hui Din، نويسنده , , Yat-Pang Chau، نويسنده , , Ming-Jaw Don، نويسنده ,
Abstract :
A series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC50 value as low as 0.022 and 0.065 nM, respectively.
Keywords :
5-Diarylisoxazole , 4 , Antimitotic agent , cytotoxicity
