Title of article
Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents
Author/Authors
Laixing Hu، نويسنده , , Zhuo-rong Li، نويسنده , , Yue-ming Wang، نويسنده , , Yanbin Wu، نويسنده , , Jiandong Jiang، نويسنده , , David W. Boykin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
1193
To page
1196
Abstract
A series of azaheterocyclic carbazole sulfonamides was synthesized and evaluated for antiproliferative activity. The most potent compounds N-(2,6-dimethoxypyridine-3-yl)-9-ethyl and 9-methylcarbazole-3-sulfonamide (13 and 14) gave significant cytotoxicity (IC50 = 122 and 101 nM). Compound 13 displayed submicromolar activities against seven human tumor cell lines. The SARs of this series of sulfonamides which includes the influence of azaheterocycle rings, sulfonamide linkage, and the carbazole ring are described.
Keywords
antiproliferative agents , sulfonamides
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797816
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