Title of article :
Identification of arylsulfonamides as Aquaporin 4 inhibitors
Author/Authors :
Vincent J. Huber، نويسنده , , Mika Tsujita، نويسنده , , Maya Yamazaki، نويسنده , , Kenji Sakimura، نويسنده , , Tsutomu Nakada، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at 20 μM in an in vitro functional assay. AZA was found to have an IC50 against AQP4 of 0.9 μM. Phloretin was inactive under the same conditions.
Keywords :
inhibitors , Acetazolamide , 6-Ethoxybenzothiazole-2-sulfonamide , EZA , Phloretin , Aquaporin 4 , AQP4 , AZA
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
