Title of article :
3-Hydroxychromones as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation
Author/Authors :
Jinho Lee، نويسنده , , Taesik Park، نويسنده , , ShinWu Jeong، نويسنده , , Kyoung-Hee Kim، نويسنده , , ChangYong Hong، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.
Keywords :
Isothiazolidine 1 , 1-dioxide , CDK2 , 3-Hydroxychromone
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
