Title of article
Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists
Author/Authors
Georg Jaeschke، نويسنده , , Richard Porter، نويسنده , , Bernd Büttelmann، نويسنده , , Simona M. Ceccarelli، نويسنده , , Wolfgang Guba، نويسنده , , Bernd Kuhn، نويسنده , , Sabine Kolczewski، نويسنده , , J?rg Huwyler، نويسنده , , Vincent Mutel، نويسنده , , Jens-Uwe Peters، نويسنده , , Theresa Ballard، نويسنده , , Eric Prinssen، نويسنده , , Eric Vieira، نويسنده , , Jürgen Wichmann، نويسنده , , Will Spooren، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
1307
To page
1311
Abstract
Optimization of affinity and microsomal stability led to identification of the potent, metabolically stable fenobam analog 4l. Robust in vivo efficacy of 4l was demonstrated in four different models of anxiety. Additionally, a ligand based pharmacophore alignment of fenobam and MPEP is proposed.
Keywords
mGluR5 , Fenobam , Anxiety , MPEP , Pharmacophore
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797840
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