Author/Authors :
Luca Banfi، نويسنده , , Andrea Basso، نويسنده , , Gianluca Damonte، نويسنده , , Federico De Pellegrini، نويسنده , , Andrea Galatini، نويسنده , , Giuseppe Guanti، نويسنده , , Ilaria Monfardini، نويسنده , , Renata Riva، نويسنده , , Carlo Scapolla، نويسنده ,
Abstract :
The synthesis of new conformationally biased cyclic pentapeptides, incorporating the RGD sequence, and built around a tetrahydroazoninone scaffold, is reported. They exhibit interesting activity towards integrin αVβ3 and a remarkable selectivity in comparison with integrin αVβ5.
Keywords :
Integrin ligands , peptidomimetics , angiogenesis , Azoninones
