Author/Authors :
Rosa Arienzo، نويسنده , , Sue Cramp، نويسنده , , Hazel J. Dyke، نويسنده , , Peter M. Lockey، نويسنده , , Dennis Norman، نويسنده , , Alan G. Roach، نويسنده , , Phil Smith، نويسنده , , Melanie Wong، نويسنده , , Stephen P. Wren، نويسنده ,
Abstract :
We have modified the previously reported 2-aminoquinoline 1 to provide two novel series of MCH-1R antagonists. Representative compounds from the quinazoline and benzimidazole series have been shown to be potent and selective, with promising in vitro eADME profiles.
