Title of article
Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor
Author/Authors
Takayoshi Suzuki، نويسنده , , Shinya Hisakawa، نويسنده , , Yukihiro Itoh، نويسنده , , Sakiko Maruyama، نويسنده , , Mineko Kurotaki، نويسنده , , Hidehiko Nakagawa، نويسنده , , Naoki Miyata، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
1558
To page
1561
Abstract
To identify prodrugs of a thiolate histone deacetylase inhibitor NCH-31 that show potent antiproliferative activity and are stable in human plasma, we synthesized several candidate prodrugs of NCH-31. Among these compounds, S-2-methyl-3-phenylpropanoyl compound 2 showed more potent antiproliferative activity and higher stability in human plasma than S-isobutyryl compound NCH-51.
Keywords
Histone deacetylase inhibitor , Antiproliferative agent , prodrug
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797886
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