Title of article
Antiviral activity of berberine and related compounds against human cytomegalovirus
Author/Authors
Kyoko Hayashi، نويسنده , , Kazuki Minoda، نويسنده , , Yasuo Nagaoka، نويسنده , , Toshimitsu Hayashi، نويسنده , , Shinichi Uesato، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
3
From page
1562
To page
1564
Abstract
Berberine chloride (1) and the structurally related compounds were assessed for the anti-human cytomegalovirus (HCMV) activity using the plaque assay. The anti-HCMV activity (IC50 0.68 μM) of 1 was equivalent to that (IC50 0.91 μM) of ganciclovir (GCV). The mechanism of action by which 1 inhibits the replication of HCMV is presumed to be different from that of GCV; 1 would interfere with intracellular events after virus penetration into the host cells and before viral DNA synthesis.
Keywords
Berberine , Human cytomegalovirus , Papaverine , Ganciclovir
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797887
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