Title of article
Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J
Author/Authors
Maurizio Botta، نويسنده , , Silvia Armaroli، نويسنده , , Daniele Castagnolo، نويسنده , , Gabriele Fontana، نويسنده , , Paula Pera، نويسنده , , Ezio Bombardelli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
1579
To page
1583
Abstract
A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 μM when tested in combination with paclitaxel.
Keywords
Taxoids , 2-Deacetoxytaxinine J , Multidrug resistance (MDR)
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797891
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