Title of article :
Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J
Author/Authors :
Maurizio Botta، نويسنده , , Silvia Armaroli، نويسنده , , Daniele Castagnolo، نويسنده , , Gabriele Fontana، نويسنده , , Paula Pera، نويسنده , , Ezio Bombardelli، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 μM when tested in combination with paclitaxel.
Keywords :
Taxoids , 2-Deacetoxytaxinine J , Multidrug resistance (MDR)
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
