Title of article :
Synthesis and cytotoxicity of novel fatty acid-nucleoside conjugates
Author/Authors :
Yun-Xiao Zhang، نويسنده , , Gui-Fu Dai، نويسنده , , L.E. Wang، نويسنده , , Jing-Chao Tao، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
N3-Hydroxyethyltegafur (3) was synthesized in 91.0% yield under a new condition. A series of novel fatty acid esters of 3 were synthesized. These fatty acid-nucleoside conjugates have shown cytotoxicities against Ec9706 cells and A549 cells, and the structure activity relationship was discussed.
Keywords :
Tegafur , Conjugates , Fatty acid , cytotoxicity , synthesis
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
