Title of article
Design, synthesis, and biological evaluation of novel analogues of archazolid: A highly potent simplified V-ATPase inhibitor
Author/Authors
Dirk Menche، نويسنده , , Jorma Hassfeld، نويسنده , , Florenz Sasse، نويسنده , , Markus Huss، نويسنده , , Helmut Wieczorek، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
1732
To page
1735
Abstract
Novel analogues of the V-ATPase inhibitors archazolid A and B with modifications of the free hydroxyl groups and the side chain were designed by molecular modeling, synthesized by derivatization of the parent natural product and evaluated for V-ATPase inhibition and growth inhibition of murine connective tissue cells.
Keywords
Archazolid , analogues , Structure–activity data , V-ATPase , modeling
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797923
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