Author/Authors :
Anne-Marie Liberatore، نويسنده , , Jocelyne Schulz، نويسنده , , Christine Favre-Guilmard، نويسنده , , Jacques Pommier، نويسنده , , Jacques Lannoy، نويسنده , , Emilia Pawlowski، نويسنده , , Marie-Anne Barthelemy، نويسنده , , Marion Huchet، نويسنده , , Michel Auguet، نويسنده , , Pierre-Etienne Chabrier، نويسنده , , Dennis Bigg، نويسنده ,
Abstract :
A series of 4-arylimidazole carbamates was synthesized and their binding affinities to the site-2 sodium (Na+) channel were determined. SAR studies led to the identification of compound 10, a potent Na+ channel blocker which was efficacious in pain models in vivo.
