Title of article
Production of aminoglycosides in non-aminoglycoside producing Streptomyces lividans TK24
Author/Authors
Bimala Subba، نويسنده , , Nagendra Prasad Kurumbang، نويسنده , , Young Soo Jung، نويسنده , , Yeo Joon Yoon، نويسنده , , Hei Chan Lee، نويسنده , , Kwangkyoung Liou، نويسنده , , Jae Kyung Sohng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
1892
To page
1896
Abstract
The pRBM4 cosmid, which harbors a putative cluster of genes spanning a 31.8-kb chromosomal region of the ribostamycin producer Streptomyces ribosidificus ATCC 21294, was heterologously expressed in Streptomyces lividans TK24. ESI-MS/MS, HPLC, and LC-ESI MS analyses showed that the transformation gave rise to ribostamycin production in various culture broths. This is the first report of heterologous aminoglycoside production.
Keywords
aminoglycoside , Heterologous expression , Ribostamycin , Streptomyces lividans TK 24
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797953
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