Synthesis and biological evaluation of unprecedented classes of spiro-β-lactams and azido-β-lactams as acyl-CoA:cholesterol acyltransferase inhibitors

Unprecedented classes of four- and five-membered hydroxyl-spiro-β-lactams and hydroxyl-azido-β-lactams were prepared via regioselective ring opening of hydroxyl-epoxides. The potential of these particular β-lactams as biologically active compounds has been confirmed by the results obtained in ACAT inhibition assays.