Title of article
N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors
Author/Authors
Paul V. Fish، نويسنده , , M. Jonathan Fray، نويسنده , , Alan Stobie، نويسنده , , Florian Wakenhut، نويسنده , , Gavin A. Whitlock، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
2022
To page
2025
Abstract
A series of N-benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amine monoamine reuptake inhibitors are described. Selective dual 5-HT and NA reuptake inhibition was achieved, and analogues with weak CYP2D6 inhibition, good human in vitro metabolic stability and wide ligand selectivity, such as 12b, were identified.
Keywords
Serotonin reuptake , Metabolic stability , HERG , SNRI , Noradrenaline reuptake
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797979
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