Title of article
Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives
Author/Authors
Shi-Wu Chen، نويسنده , , Yunhua Wang، نويسنده , , Yan Jin، نويسنده , , Xuan Tian، نويسنده , , Yong-Tang Zheng، نويسنده , , Du-Qiang Luo، نويسنده , , Yong-Qiang Tu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
2091
To page
2095
Abstract
In order to explore the range of biological activities of the podophyllotoxin compound class, a novel series of derivatives of podophyllotoxin, which were conjugates containing stavudine and different structural podophyllotoxin analogues, were designed, synthesized, and evaluated for their anti-HIV-1 activities in vitro. Among these compounds, 19d and 19c showed the highest anti-HIV-1 activities with EC50 values of 0.17 and 0.29 μM and TI values of 466.9 and 354.5, respectively.
Keywords
Anti-HIV , d4T , Podophyllotoxin , Totoxicity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797992
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