Title of article
SAR studies on a novel series of human cytomegalovirus primase inhibitors
Author/Authors
X. Chen، نويسنده , , J. Adrian، نويسنده , , James T. Cushing، نويسنده , , H. DiMaio، نويسنده , , L. Liang، نويسنده , , V. Mayorga، نويسنده , , S. Miao، نويسنده , , M.G. Peterson، نويسنده , , J.P. Powers، نويسنده , , F. Spector، نويسنده , , C. Stein، نويسنده , , M. Wright، نويسنده , , D. Xu، نويسنده , , Q. Ye، نويسنده , , J. Jaen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
2188
To page
2192
Abstract
A novel series of imidazolylpyrimidines were found to possess inhibitory activity against the human CMV UL70 primase. Extensive SAR studies on an HTS lead led to potent, orally bioavailable compounds with anti-CMV IC50 values of 150 nM in both viral yield and viral DNA replication assays and with a much reduced cytotoxicity compared to marketed treatments ganciclovir and cidofovir.
Keywords
Anti-viral , cytomegalovirus , hCMV , Primase , inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798007
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