Author/Authors :
Lauren Monovich، نويسنده , , Benjamin Mugrage، نويسنده , , Elizabeth Quadros، نويسنده , , Karen Toscano، نويسنده , , Ruben Tommasi، نويسنده , , Stacey LaVoie، نويسنده , , H. Eugene Liu، نويسنده , , Zhengming Du، نويسنده , , Daniel LaSala، نويسنده , , William Boyar، نويسنده , , Paul Steed، نويسنده ,
Abstract :
Halopemide, which was identified by HTS to inhibit phospholipase D2 (PLD2), provided the basis for an exploratory effort to identify potent inhibitors of PLD2 for use as inflammatory mediators. Parallel synthesis and purification were utilized to rapidly identify orally available amide analogs derived from indole 2-carboxylic acids with superior potency versus PLD2.
