Author/Authors :
Robert G. Wei، نويسنده , , Marc Adler، نويسنده , , David Davey، نويسنده , , Elena Ho، نويسنده , , Raju Mohan، نويسنده , , Mark Polokoff، نويسنده , , Jih-Lie Tseng، نويسنده , , Marc Whitlow، نويسنده , , Wei Xu، نويسنده , , Shendong Yuan، نويسنده , , Gary Phillips، نويسنده ,
Abstract :
A new series of 1-(1,3-benzodioxol-5-ylmethyl)-3-[4-(1H-Imidazol-1-yl)phenoxy]-piperidine analogs were designed and identified as potent and selective inhibitors of NO formation based both on the crystal structure of a murine iNOS Δ114 monomer domain/ inhibitor complex and inhibition of the NO formation in human A172 cell assays. Compound 12S showed high potency and high iNOS selectivity versus nNOS and eNOS.
