Title of article
Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists
Author/Authors
Mingzhu Zhang، نويسنده , , Junko Tamiya، نويسنده , , Phi Linh Nguyen Thi، نويسنده , , Martin W. Rowbottom، نويسنده , , Brian Dyck، نويسنده , , Troy D. Vickers، نويسنده , , Jonathan Grey، نويسنده , , David A. Schwarz، نويسنده , , Christopher E. Heise، نويسنده , , Jason Haelewyn، نويسنده , , Monica S. Mistry، نويسنده , , Val S. Goodfellow، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
2535
To page
2539
Abstract
A series of thienopyrimidinone bis-aminopyrrolidine ureas were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor-1. These compounds exhibit potent binding affinity (Ki = 3 nM) and good in vitro metabolic stability.
Keywords
obesity , Melanin-concentrating hormone , MCH
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798076
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