Author/Authors :
Michael A. Letavic، نويسنده , , John M. Keith، نويسنده , , Kiev S. Ly، نويسنده , , Ann J. Barbier، نويسنده , , Jamin D. Boggs، نويسنده , , Sandy J. Wilson، نويسنده , , Brian Lord، نويسنده , , Timothy W. Lovenberg، نويسنده , , Nicholas I. Carruthers، نويسنده ,
Abstract :
A series of novel tetrahydronaphthyridine-based histamine H3 ligands that have serotonin reuptake transporter inhibitor activity is described. The 1,2,3,4-tetrahydro-2,6-naphthyridine scaffold is assembled via the addition of a nitrostyrene to a metalated pyridine followed by reduction and cyclization to form the naphthyridine. In vitro biological data for these novel compounds are discussed.
