Title of article
Aryl sulfonamido indane inhibitors of the Kv1.5 ion channel
Author/Authors
Michael F. Gross، نويسنده , , Serge Beaudoin، نويسنده , , Grant McNaughton-Smith، نويسنده , , George S. Amato، نويسنده , , Neil A. Castle، نويسنده , , Christine Huang، نويسنده , , Anruo Zou، نويسنده , , Weifeng Yu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
2849
To page
2853
Abstract
A collection of aryl sulfonamido indanes based on the lead compound 1 was synthesized and evaluated for Kv1.5 inhibitory activity. Kv1.5 inhibitors have the potential to be atrium-selective agents for treatment of atrial fibrillation. (1R,2R)-1 has an IC50 of 0.033 μM against Kv1.5 and is selective against other cardiac ion channels, including hERG.
Keywords
Kv1.5 inhibitors , Atrial fibrillation
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798136
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