Title of article :
Synthesis and structure–activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1
Author/Authors :
Ginny D. Ho، نويسنده , , Ana Bercovici، نويسنده , , Deen Tulshian، نويسنده , , William J. Greenlee، نويسنده , , Ahmad Fawzi، نويسنده , , April Smith-Torhan، نويسنده , , Hongtao Zhang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
A series of 4-hydroxy-4-phenylpiperidines have been synthesized and bind to the nociceptin receptor with high affinity. The synthesis and structure–activity relationships at the N-1 and C-4 are described.
Keywords :
Nociceptin/orphin FQ , Nociceptin receptor (NOP) , Opioid receptor-like-1 (ORL-1) , Opioid receptors (MOP , KOP , DOP) , G protein-coupled receptor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
