Title of article
Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II
Author/Authors
Koushi Hidaka، نويسنده , , Tooru Kimura، نويسنده , , Yumi Tsuchiya، نويسنده , , Mami Kamiya، نويسنده , , Adam J. Ruben، نويسنده , , Ernesto Freire، نويسنده , , Yoshio Hayashi، نويسنده , , Yoshiaki Kiso، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
3048
To page
3052
Abstract
Based on a highly potent allophenylnorstatine-containing inhibitor, KNI-10006, against the plasmepsins of Plasmodium falciparum, we synthesized a series of tripeptide-type compounds with various N-terminal moieties and evaluated their inhibitory activities against plasmepsin II. Certain phenylacetyl derivatives exhibited extremely high affinity with Ki values of less than 0.1 nM suggesting successful hydrophobic interactions.
Keywords
Aspartic protease , malaria , Plasmepsin inhibitor , Peptidomimetic , Allophenylnorstatine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798175
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