Author/Authors :
Franco Chimenti، نويسنده , , Bruna Bizzarri، نويسنده , , Adriana Bolasco، نويسنده , , Daniela Secci، نويسنده , , Paola Chimenti، نويسنده , , Simone Carradori، نويسنده , , Arianna Granese، نويسنده , , Daniela Rivanera، نويسنده , , Daniela Lilli، نويسنده , , Alessandra Zicari، نويسنده , , M. Maddalena Scaltrito، نويسنده , , Francesca Sisto، نويسنده ,
Abstract :
A novel class of selective anti-Helicobacter pylori agents, 2-oxo-2H-chromene-3-carboxamide derivatives, were prepared and evaluated for their anti-bacterial activity. All synthesized compounds showed little or no activity against different species of Gram-positive and Gram-negative bacteria and against various strains of pathogenic fungi. Some of them exhibited a potent and specific inhibitory effect on the growth of H. pylori, including metronidazole-resistant strains, in the 0.0039–16 μg/mL MIC range. A cytotoxic screening by the Trypan blue dye exclusion assay was also carried out on the most active compounds as anti-H. pylori agents. Among the derivatives examined for their cytotoxic potential, a number of them induced low cytotoxic effects.
