Title of article
Dual M3 antagonists-PDE4 inhibitors. Part 2: Synthesis and SAR of 3-substituted azetidinyl derivatives
Author/Authors
Laurent Provins، نويسنده , , Bernard Christophe، نويسنده , , Pierre Danhaive، نويسنده , , Jacques Dulieu، نويسنده , , Michel Gillard، نويسنده , , Luc Quéré، نويسنده , , Karin Stebbins، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
3077
To page
3080
Abstract
Introduction of 3-substituted azetidinyl substituents onto the 4,6-diaminopyrimidine scaffold allowed the improvement of PDE4 inhibiting activities. Preliminary in vivo activity in pulmonary inflammation models is reported.
Keywords
COPD , Pyrimidine , Azetidine , Phosphodiesterase , Muscarinic receptor(s)
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798180
Link To Document