Title of article
Synthesis, biological evaluations, and tubulin binding poses of C-2α sulfur linked taxol analogues
Author/Authors
Lei Wang، نويسنده , , Ana A. Alcaraz، نويسنده , , Ruth Matesanz، نويسنده , , Chun-Gang Yang، نويسنده , , Isabel Barasoain، نويسنده , , J. Fernando D?az، نويسنده , , Ye-Zhi Li، نويسنده , , James P. Snyder، نويسنده , , Wei-Shuo Fang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
3191
To page
3194
Abstract
In combination with chemical modifications, bioassays, and computational simulation techniques, C-2 benzoylthio, and benzylthio taxoids were synthesized, biologically evaluated, and their binding conformations rationalized, in order to probe the interaction of taxane molecule with β-tubulin.
Keywords
Paclitaxel , Taxol analogues , Binding conformation , SAR studies
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798203
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