Author/Authors :
Gang Zhao، نويسنده , , Rajesh R. Iyengar، نويسنده , , Andrew S. Judd، نويسنده , , Barbara Cool، نويسنده , , William Chiou، نويسنده , , Lemma Kifle، نويسنده , , Ernst Frevert، نويسنده , , Hing Sham، نويسنده , , Philip R. Kym، نويسنده ,
Abstract :
AMP-activated protein kinase (AMPK) is well established as a sensor and regulator of intracellular and whole-body energy metabolism. A high-throughput screen was performed in order to identify chemotypes that are bound by AMPK. A novel thienopyridone compound (1) was identified and subsequently optimized. The structure–activity relationships that emerged from this effort are described.
