Title of article
Piperidine amides as 11β-hydroxysteroid dehydrogenase type 1 inhibitors
Author/Authors
Katarina Flyrén، نويسنده , , Lars O. Bergquist، نويسنده , , Victor M. Castro، نويسنده , , Christopher Fotsch، نويسنده , , Lars Johansson، نويسنده , , David J. St. Jean Jr.، نويسنده , , Lori Sutin، نويسنده , , Meredith Williams، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
3421
To page
3425
Abstract
A series of piperidine amide inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) were identified via modifications of the HTS hit compound 1. The synthesis, in vitro biological evaluation, and structure–activity relationship of these compounds are presented.
Keywords
metabolic syndrome , Piperidine amides , 11?-HSD1 inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798247
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