Author/Authors :
Satish K. Chitneni، نويسنده , , Christophe M. Deroose، نويسنده , , Humphrey Fonge، نويسنده , , Rik Gijsbers، نويسنده , , Natalia Dyubankova، نويسنده , , Jan Balzarini، نويسنده , , Zeger Debyser، نويسنده , , Luc Mortelmans، نويسنده , , Alfons M. Verbruggen، نويسنده , , Guy M. Bormans، نويسنده ,
Abstract :
An iodine-123 labeled bicyclic nucleoside analogue ([123I]-4) has been synthesized and evaluated as a potential single photon emission tomography (SPECT) reporter probe for the non-invasive imaging of expression of the varicella zoster virus thymidine kinase (VZV-tk) reporter gene. In vitro enzymatic assays revealed that the non-radioactive mono-iodo derivative 4 has good affinity for VZV-TK (IC50: 4.2 μM). Biodistribution of [123I]-4 was examined in normal mice. Evaluation of [123I]-4 in HEK-293T cells showed 1.74-fold higher accumulation in VZV-TK-expressing cells compared to control cells.
Keywords :
BCNA , iodine-123 , molecular imaging , SPECT , Radiopharmaceutical
