Author/Authors :
Anthony B. Pinkerton، نويسنده , , Tom T. Lee، نويسنده , , Timothy Z. Hoffman، نويسنده , , Yan Wang، نويسنده , , Mehmet Kahraman، نويسنده , , Travis G. Cook، نويسنده , , Daniel Severance، نويسنده , , Timothy C. Gahman، نويسنده , , Stewart A. Noble، نويسنده , , Andrew K. Shiau and David A. Agard، نويسنده , , Robert L. Davis، نويسنده ,
Abstract :
We have identified and synthesized a series of thiophene containing inhibitors of kinesin spindle protein. SAR studies led to the synthesis of 33, which was co-crystallized with KSP and determined to bind to an allosteric pocket previously described for other known KSP inhibitors.
Keywords :
Eg5 , KSP , thiophenes , Anti-mitotics , Kinesin spindle protein
