Title of article
3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2
Author/Authors
Gabor Butora، نويسنده , , Richard Jiao، نويسنده , , William H. Parsons، نويسنده , , Pasquale P. Vicario، نويسنده , , Hong Jin، نويسنده , , Julia M. Ayala، نويسنده , , Margaret A. Cascieri، نويسنده , , Lihu Yang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
3636
To page
3641
Abstract
A series of low molecular weight antagonists of both the human and murine CC chemokine receptor 2, containing a 1-alkyl-3-(3-methyl-4-spiroindenylpiperidine)-substituted cyclopentanecarboxamide, is described. A SAR study of the C1 substituent revealed that short, branched alkyl groups such as isopropyl, isobutyl, or cyclopropyl are optimal for both human and murine CCR2 binding activity.
Keywords
CCR2 receptor antagonists , chemokines
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798285
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