Title of article
Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent γ-secretase inhibitors
Author/Authors
Michael G. Yang، نويسنده , , Jian Liang Shi، نويسنده , , Dilip P. Modi، نويسنده , , Jennifer Wells، نويسنده , , Brian M. Cochran، نويسنده , , Mark A. Wolf، نويسنده , , Lorin A. Thompson، نويسنده , , Mercy M. Ramanjulu، نويسنده , , Arthur H. Roach، نويسنده , , Robert Zaczek، نويسنده , , David W. Robertson، نويسنده , , Ruth R. Wexler، نويسنده , , Richard E. Olson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
3910
To page
3915
Abstract
We report the synthesis of benzoazepine-derived cyclic malonamides (2) and aminoamides (3) as γ-secretase inhibitors for the potential treatment of Alzheimer’s disease. The in vitro structure–activity relationships of 2 and 3 along with dog pharmacokinetic results are described.
Keywords
Gamma-secretase , Benzoazepinone , inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798337
Link To Document