Title of article
The discovery of long acting β2-adrenoreceptor agonists
Author/Authors
Alan D. Brown، نويسنده , , Mark E. Bunnage، نويسنده , , Paul A. Glossop، نويسنده , , Kim James، نويسنده , , Rhys Jones، نويسنده , , Charlotte A.L. Lane، نويسنده , , Russell A. Lewthwaite، نويسنده , , Simon Mantell، نويسنده , , Christelle Perros-Huguet، نويسنده , , David A. Price، نويسنده , , Mike Trevethick، نويسنده , , Rob Webster، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
4012
To page
4015
Abstract
The design and profile of a series of saligenin containing long acting β2-adrenoreceptor agonists is described. Evaluation of these analogues using a guinea-pig tissue model demonstrates that analogues within this series have significantly longer durations of action than salmeterol and have the potential for a once daily profile in human.
Keywords
?2 , COPD , Duration of action , asthma , Salmeterol , formoterol , bioavailability
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798358
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