Author/Authors :
Ki Dong Koo، نويسنده , , Min Jung Kim، نويسنده , , Sungsub Kim، نويسنده , , Kyoung-Hee Kim، نويسنده , , Sang Yong Hong، نويسنده , , Gwong-Cheung Hur، نويسنده , , Hyeon Joo Yim، نويسنده , , Geun Tae Kim، نويسنده , , Hee Oon Han، نويسنده , , O Hwan Kwon، نويسنده , , Tae Sik Kwon، نويسنده , , Jong Sung Koh، نويسنده , , Chang-Seok Lee، نويسنده ,
Abstract :
Synthesis of a novel series of DPPIV inhibitors with 1,2,4- and 1,3,4-oxadiazolyl ketone derivatives and its structure–activity relationships are discussed. Compound 18h showed good inhibitory activity against DPPIV and favorable pharmacokinetic properties. In vivo pharmacodynamic efficacy and co-crystal structure of compound 18h with DPPIV is also described.
