Title of article
Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors
Author/Authors
Takayoshi Suzuki، نويسنده , , Shinya Hisakawa، نويسنده , , Yukihiro Itoh، نويسنده , , Nobuaki Suzuki، نويسنده , , Katsumasa Takahashi، نويسنده , , Masatoshi Kawahata، نويسنده , , Kentaro Yamaguchi، نويسنده , , Hidehiko Nakagawa، نويسنده , , Naoki Miyata، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
4208
To page
4212
Abstract
Aiming to develop selective anticancer drugs, we designed and synthesized three disulfides bearing a folic acid moiety as candidate folate receptor (FR)-targeted prodrugs of thiolate histone deacetylase inhibitors. Among them, compound 1 displayed growth-inhibitory activity toward folate receptor-positive MCF-7 breast cancer cells. The activity of 1 was significantly reduced by free folic acid, suggesting that cellular uptake of 1 is mediated by FR.
Keywords
Histone deacetylase inhibitor , Selective anticancer activity , Folate conjugate , prodrug
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798396
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