Author/Authors :
Ronghui Lin، نويسنده , , Peter J. Connolly، نويسنده , , Yanhua Lu، نويسنده , , George Chiu، نويسنده , , Shengjian Li، نويسنده , , Yang Yu، نويسنده , , Shenlin Huang، نويسنده , , Xun Li، نويسنده , , Stuart L. Emanuel، نويسنده , , Steven A. Middleton، نويسنده , , Robert H. Gruninger، نويسنده , , MARY ADAMS، نويسنده , , Angel R. Fuentes-Pesquera، نويسنده , , Lee M. Greenberger، نويسنده ,
Abstract :
A series of 3,5-disubstituted pyrazolo[3,4-b]pyridine cyclin-dependent kinase (CDK) inhibitors was synthesized. These compounds showed potent and selective CDK inhibitory activities and inhibited in vitro cellular proliferation in cultured human tumor cells. Selected compounds were evaluated in an in vivo tumor xenograft model. The synthesis and biological evaluation of these pyrazolo[3,4-b]pyridines and related compounds are reported.
