Title of article :
Hypoxia-driven elimination of thiopurines from their nitrobenzyl prodrugs
Author/Authors :
Peter Thomson، نويسنده , , Matthew A. Naylor، نويسنده , , Michael R.L. Stratford، نويسنده , , Gemma Lewis، نويسنده , , Sally Hill، نويسنده , , Kantilal B. Patel، نويسنده , , Peter Wardman، نويسنده , , Peter D. Davis، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
A novel bioreductive prodrug of 6-thioguanine, 2-amino-6-[2-(4-nitrophenyl)prop-2-ylsulfanyl]-9H-purine, containing a gem-dimethyl thioether linkage, was synthesised and compared with its unsubstituted analogue. In A549 whole cell experiments hypoxia selective release of 6-thioguanine was observed with the substituted prodrug only.
Keywords :
Hypoxia , Thiopurine , Targeting , delivery , tumor , A549 , Thioguanine , mercaptopurine , Nitrobenzyl
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
