Title of article :
Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma
Author/Authors :
Bharat Lagu، نويسنده , , Chrissy Gerchak، نويسنده , , Meng Pan، نويسنده , , Cuifen Hou، نويسنده , , Monica Singer، نويسنده , , Ravi Malaviya، نويسنده , , Michele Matheis، نويسنده , , Gil Olini، نويسنده , , Druie Cavender، نويسنده , , Michael Wachter، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Pages :
5
From page :
4382
To page :
4386
Abstract :
A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure–activity relationships in the series are described herein along with some detailed characterization of the interesting compounds.
Keywords :
CCR2 antagonist , Chemotaxis , MCP-1 , asthma , Quaternary ammonium salt , Chemokine receptor-2 , monocytes
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2007
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
798430
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=798430
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