Title of article
Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4 receptor
Author/Authors
Lydie Poitout، نويسنده , , Valérie Brault، نويسنده , , Carole Sackur، نويسنده , , Sonia Bernetière، نويسنده , , José Câmara، نويسنده , , Pascale Plas، نويسنده , , Pierre Roubert، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
4464
To page
4470
Abstract
A novel series of benzimidazoles was identified and optimized, leading to the discovery of potent and selective antagonists of the human melanocortin-4 receptor. In addition, compound 5i was shown to cross the blood–brain barrier after intravenous dosing in rats.
Keywords
Benzimidazole , Melanocortin-4 receptor , Antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798444
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